Project description
The ribosome-inactivating proteins (RIPs) possess RNA N-glycosidase activity that depurinates the major rRNA, thus damaging ribosomes in an irreversible manner and arresting protein synthesis. RIPs are presently classified as rRNA N-glycosidase in the enzyme nomenclature (EC 3.2.2.22) and do exhibit other enzymatic activities such as ribonuclease and deoxyribonuclease activities. RIPs have been shown to manifest abortifacient, anti-tumor, anti-viral and anti-microbial activities (Kaur et al., 2020). We have recently shown that RIPs possess anti-tumor activity such as arresting the growth of breast cancers (Kaur et al., 2019). To augment the therapeutic potential of a protein, the purified protein should be delivered, without degradation to the diseased cells.
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