Project description
Glioblastoma (GBM) is one of the most aggressive and invasive brain tumors, characterized by rapid progression and resistance to conventional therapies. Traditional single-agent treatments often fail to fully suppress its invasive behaviour, as tumour cells use multiple proteins and receptors to invade. Emerging research highlights the promise of multi-target therapeutic strategies that simultaneously inhibit multiple signaling pathways involved in GBM invasion and migration. These combined approaches aim to overcome the limitations of single pharmaceutical agents by addressing the redundancy and adaptability of glioblastoma cells. By targeting diverse mechanisms such as ion channel inhibition, matrix degradation, cell motility, angiogenesis, and immune evasion, multi-target therapeutics can more effectively disrupt the tumor’s ability to infiltrate surrounding brain tissue. Work in our group has identified pharmaceutical agents from natural agents that are effective in limiting cancer cell invasion. This project will explore the effect of combination of these novel agents with known inhibitors on limiting tumour cell invasion. Molecular biology, cell culture and electrophysiology/swelling assays using Xenopus oocytes will be used to achieve the aims in this project.
Assumed knowledge
biology, biotechnology
Supervisors research focus
Cancer biology and improving plant abiotic stress tolerance.
Note: You need to register interest in projects from different supervisors (not a number of projects with the one supervisor).
You must also contact each supervisor directly to discuss both the project details and your suitability to undertake the project.